Senior Principal Scientist (all genders) - External API Development for New Chemical Entities

At Bayer we’re visionaries, driven to solve the world’s toughest challenges and striving for a world where ,Health for all, Hunger for none’ is no longer a dream, but a real possibility. We’re doing it with energy, curiosity and sheer dedication, always learning from unique perspectives of those around us, expanding our thinking, growing our capabilities and redefining ‘impossible’. There are so many reasons to join us. If you’re hungry to build a varied and meaningful career in a community of brilliant and diverse minds to make a real difference, there’s only one choice.Senior Principal Scientist (all genders) - External API Development for New Chemical Entities You are an experienced synthetic and process chemist with the ambition to shape the chemical foundation of our R&D pipeline for new chemical entities (NCEs) by designing, developing, and enabling synthetic routes that evolve into robust API manufacturing processes in partnership with our external CDMO network.In this Drug Substance (DS) Lead position within global CMC teams, you define and drive the DS strategy and are accountable for the DS contribution to the overall CMC package. Serving as the central interface between internal stakeholders and external partners, you lead chemical process development and API supply activities, enabling phase-appropriate, scalable, and sustainable manufacturing processes that ensure timely API delivery, robust product quality, and cost efficiency.YOUR TASKS AND RESPONSIBILITIESProvide scientific leadership for the design, assessment, and optimization of synthetic routes for new APIs in preclinical and clinical phases, with a focus on speed, quality, cost, sustainability, and process understandingRepresent Drug Substance (DS) in global CMC development project teams and contribute to key scientific, strategic, and portfolio decisions, while ensuring a coherent two-way flow of strategy, decisions, risks, and progress between the internal global CMC team and external CDMO activitiesGuide and challenge route design and synthetic methodology choices at external CDMOs, translating SAR-driven chemistry into scalable routes for preclinical and clinical supply and future production in alignment with the internal DS development strategyOversee external API campaigns for toxicology studies and clinical trials, including planning, risk assessment, supply-demand alignment, and budget oversightSteer process transfers between external partners and into internal development or external manufacturing, ensuring knowledge continuity and phase-appropriate documentationContribute to robust, phase-appropriate control strategies. Co-author and review the Drug Substance sections of regulatory filings (IND/IMPD and briefing documents) and support responses to health authority questionsProvide CMC DS assessments for in-licensing opportunitiesProvide chemical expertise and pragmatic troubleshooting across the internal and external manufacturing network. Actively contribute to the chemistry community by sharing knowledge and driving innovation across organizational boundariesWHO YOU AREPh.D. in Chemistry or a related science, with extensive experience in the pharmaceutical industry, including an understanding of GLP/GMP and regulatory expectationsStrong background in synthetic chemistry, with an excellent understanding of reagents, methodologies, and reaction mechanisms, plus a solid grasp of analytical techniquesExperience in the CMC development of peptides is a plusExperience in steering external partners (CROs/CDMOs) or working across an external manufacturing network is a clear advantageProven ability to represent chemistry and Drug Substance in interdisciplinary CMC or project teams and to act as an accountable interface between the internal organization and external partnersA strategic thinker with the ability to think innovatively, develop and analyze multiple solutions to complex chemistry problems, and challenge the status quoStrong communication and project management skills across scientific disciplines, cultures, and organizational boundaries, combined with assertiveness, service orientation, and enjoyment of cross-functional teamworkFluency in English (negotiation level), both written and spoken; German is an asset and willingness to learn German is requiredWHAT WE OFFEROur benefits package is flexible, appreciative, and tailored to your lifestyle, because: What matters to you, matters to us!We ensure your financial stability with a competitive salary between 109.800 and 138.500 per year (full-time) plus a variable component and a global equity-based cash plan. Your compensation is based on your qualifications, skills, and professional experience. Your family is a top priority. We offer loving company daycare centers at multiple locations, support in finding childcare, time off for the care of elderly or dependent family members, summer camps for children, and much more.We support your professional growth by providing access to learning and development opportunities, training programs through the Bayer Learning Academy, development dialogues, as well as coaching and mentoring programs.We promote health awareness and opportunities for selfcare through various measures, such as free health checks with the company doctor.We embrace diversity by providing an inclusive work environment in which you are welcomed, supported, and encouraged to bring your whole self to work.Be You. Be Bayer. #LI-AMSEMEA YOUR APPLICATION This is your opportunity to tackle the world’s biggest challenges with us: Maintaining our health, feeding growing populations and slowing the rate of climate change. You have a voice, ideas and perspectives and we want to hear them. Because our success begins with you. Be part of something big. Be Bayer.Bayer welcomes applications from all individuals, regardless of race, national origin, gender, age, physical characteristics, social origin, disability, union membership, religion, family status, pregnancy, sexual orientation, gender identity, gender expression or any unlawful criterion under applicable law. We are committed to treating all applicants fairly and avoiding discrimination.Location:           ​​ ​   Germany : North Rhine Westfalia : Wuppertal-Elberfeld || Germany : Berlin : Berlin​​​Division: ​               Pharmaceuticals​Reference Code:   ​