Job Description
Researcher - Functional Precision Oncology and Drug Resistance in Colorectal Cancer
- Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital- (in new tab)
- About the position
**About the Project**:
The project aims to uncover molecular mechanisms underlying intrinsic and acquired resistance to colorectal cancer therapy and to develop combination strategies that can overcome resistance and improve treatment outcomes for patients with metastatic disease.
The work builds on functional and molecular data generated from a living biobank of more than 400 patient-derived tumor organoids and corresponding tumor tissue samples, representing key molecular subgroups of colorectal cancer. By integrating cell-based modeling, drug screening, and comprehensive multi-omics profiling (genomics, epigenomics, transcriptomics, proteomics, and single-cell analyses), the project seeks to identify new therapeutic vulnerabilities that arise during treatment pressure.Key information
- Application deadline:
** **
- Employer:
**Oslo universitetssykehus HF**
- Title:
**Researcher**
- Positions:
**1**
- Full-time/part-time:
**Full-time**
- Employment type:
**Contract**
- Percentage of full-time:
**100**
- Webcruiter ID:
** **
- Start date:
** **
- End date:
** **
- Social sharing:
- Share on x- Share on LinkedIn- Share on Facebook- Position
- Full-time position for 2 years with possibility of extension. The position is financed by the Norwegian Cancer Society, and will be part of the multidisciplinary colorectal cancer translational research program at Oslo University Hospital, led by Professor Ragnhild A. Lothe, Head of Dept. Molecular Oncology. The researcher will be part of the the Functional Precision Oncology project group (leader: Kushtrim Kryeziu, PhD) and the Computational Oncology group (led by Associate Professor Anita Sveen), and collaborate with other partners in this multidisciplinary research environment.
**Qualifications**:
Required:
- PhD in cancer genomics or molecular biology
- Documented experience with multi-omics analyses and data integration
- Experience with translational cancer research
- Experience with use and/or development of bioinformatical and statistical tools in cancer research
- Excellent written and oral communication skills in English
- Ability to work independently and collaboratively within a multidisciplinary team
Desirable:
- Experience with functional precision oncology, including analyses of large-scale drug screen data Familiarity with antibody-drug conjugates (ADCs), targeted therapies, or drug combination studies and drug resistance studiesPersonal Qualities:
- Strong analytical and problem-solving skills
- Structured, detail-oriented, and reliable
- Team-oriented with good communication skills
- Motivated and enthusiastic about translational cancer research
We Offer
- A stimulating and collaborative research environment at Oslo University Hospital - The Norwegian Radium Hospital
- Access to state-of-the-art facilities for functional drug testing, molecular profiling, and secure high-performance computing
- Integration into a multidisciplinary translational research network in colorectal cancer
- Opportunities for scientific development, and career advancement
- Address:
- Ullernchausseen 70, 0379 Oslo, Norway
**Open directions**
**(in new tab)**
Contacts
**Ragnhild Adelheid Lothe**
- Seksjonsleder
**Dr. Kushtrim Kryeziu**
- Project leader
About the employer
Oslo University Hospital is a highly specialized hospital in charge of extensive regional and local hospital assignments. As Scandinavia’s largest hospital, we carry out more than 1.2 million patient treatments each year. The hospital has a nationwide responsibility for a number of national and multi-regional assignments, and has several national centers of competence. Oslo University Hospital is responsible for approximately 50 percent of all medical and health care research conducted at Norwegian hospitals, and is a significant role player within the education of a large variety of health care personnel.
- Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital- (in new tab)
- About the position
**About the Project**:
The project aims to uncover molecular mechanisms underlying intrinsic and acquired resistance to colorectal cancer therapy and to develop combination strategies that can overcome resistance and improve treatment outcomes for patients with metastatic disease.
The work builds on functional and molecular data generated from a living biobank of more than 400 patient-derived tumor organoids and corresponding tumor tissue samples, representing key molecular subgroups of colorectal cancer. By integrating cell-based modeling, drug screening, and comprehensive multi-omics profiling (genomics, epigenomics, transcriptomics, proteomics, and single-cell analyses), the project seeks to identify new therapeutic vulnerabilities that arise during treatment pressure.Key information
- Application deadline:
** **
- Employer:
**Oslo universitetssykehus HF**
- Title:
**Researcher**
- Positions:
**1**
- Full-time/part-time:
**Full-time**
- Employment type:
**Contract**
- Percentage of full-time:
**100**
- Webcruiter ID:
** **
- Start date:
** **
- End date:
** **
- Social sharing:
- Share on x- Share on LinkedIn- Share on Facebook- Position
- Full-time position for 2 years with possibility of extension. The position is financed by the Norwegian Cancer Society, and will be part of the multidisciplinary colorectal cancer translational research program at Oslo University Hospital, led by Professor Ragnhild A. Lothe, Head of Dept. Molecular Oncology. The researcher will be part of the the Functional Precision Oncology project group (leader: Kushtrim Kryeziu, PhD) and the Computational Oncology group (led by Associate Professor Anita Sveen), and collaborate with other partners in this multidisciplinary research environment.
**Qualifications**:
Required:
- PhD in cancer genomics or molecular biology
- Documented experience with multi-omics analyses and data integration
- Experience with translational cancer research
- Experience with use and/or development of bioinformatical and statistical tools in cancer research
- Excellent written and oral communication skills in English
- Ability to work independently and collaboratively within a multidisciplinary team
Desirable:
- Experience with functional precision oncology, including analyses of large-scale drug screen data Familiarity with antibody-drug conjugates (ADCs), targeted therapies, or drug combination studies and drug resistance studiesPersonal Qualities:
- Strong analytical and problem-solving skills
- Structured, detail-oriented, and reliable
- Team-oriented with good communication skills
- Motivated and enthusiastic about translational cancer research
We Offer
- A stimulating and collaborative research environment at Oslo University Hospital - The Norwegian Radium Hospital
- Access to state-of-the-art facilities for functional drug testing, molecular profiling, and secure high-performance computing
- Integration into a multidisciplinary translational research network in colorectal cancer
- Opportunities for scientific development, and career advancement
- Address:
- Ullernchausseen 70, 0379 Oslo, Norway
**Open directions**
**(in new tab)**
Contacts
**Ragnhild Adelheid Lothe**
- Seksjonsleder
**Dr. Kushtrim Kryeziu**
- Project leader
About the employer
Oslo University Hospital is a highly specialized hospital in charge of extensive regional and local hospital assignments. As Scandinavia’s largest hospital, we carry out more than 1.2 million patient treatments each year. The hospital has a nationwide responsibility for a number of national and multi-regional assignments, and has several national centers of competence. Oslo University Hospital is responsible for approximately 50 percent of all medical and health care research conducted at Norwegian hospitals, and is a significant role player within the education of a large variety of health care personnel.
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